000			02600nam a2200253Ia 4500
003			OSt
005			20250716165436.0
008			220909b |||||||| |||| 00| 0 eng d
020			_a9780470569061
040			_aCSL _beng _cCSL
041			_aeng
084			_aLZ3:(E:213) Q1 TB _qCSL
100			_aRosenbaum, Sara E. _eauthor. _9815805
245		0	_aBasic Pharmacokinetics and Pharmacodynamics _b: Integrated Textbook and Computer Simulations
260			_aNew Jersey : _bJohn Wiley, _c2011.
300			_axviii, 430p.
500			_aIncludes bibliographical references and Index 415-430p.
520			_aWith its clear, straightforward presentation, this text enables you to grasp all the fundamental concepts of pharmacokinetics and pharmacodynamics. This will allow you to understand the time course of drug response and dosing regimen design. Clinical models for concentration and response are described and built from the basic concepts presented in earlier chapters. Your understanding of the material will be enhanced by guided computer exercises conducted on a companion website. Simulations will allow you to visualize drug behavior, experiment with different dosing regimens, and observe the influence of patient characteristics and model parameters. This makes the book ideal for self-study.By including clinical models of agonism, indirect drug effects, tolerance, signal transduction, and disease progression, author Sara Rosenbaum has created a work that stands out among introductory-level textbooks in this area.You'll find several features throughout the text to help you better understand and apply key concepts:Three fictitious drugs are used throughout the text to progressively illustrate the development and application of pharmacokinetic and pharmacodynamic principlesExercises at the end of each chapter reinforce the concepts and provide the opportunity to perform and solve common dosing problemsDetailed instructions let you create custom Excel worksheets to perform simple pharmacokinetic analyses Because this is an introductory textbook, the material is presented as simply as possible. As a result, you'll find it easy to gain an accurate, working knowledge of all the core principles, apply them to optimize dosing regimens, and evaluate the clinical pharmacokinetic and pharmacodynamic literature
650			_aBasic pharmacokinetics. _9815806
650			_aPharmacodynamics.
650			_aStatistics.
942			_hLZ3:(E:213) Q1 TB _cTEXL _2CC _n0
999			_c13303 _d13303