000			02749nam a2200325Ia 4500
003			OSt
005			20251223105431.0
008			220909b |||||||| |||| 00| 0 eng d
020			_a9781936113590
037			_cTextbook
040			_aCSL _beng _cCSL
041			_aeng
084			_aK:6 P7;Q5 TK _qCSL
100			_aAllis, C. David _9858885
245		0	_aEpigenetics
250			_a2nd
260			_aNew York, _bCSHL Press: _c2015.
300			_axiv, 984p. _b: coi. ill.
500			_aAppendix 943-966p.; Index 967-984p.
520			_aIn many biological processes the regulation of gene expression involves epigenetic mechanisms. In this new edition of Epigenetics, 36 chapters written by experts in the field introduce and explain epigenetic effects from many perspectives. These include the varied molecular mechanisms underpinning epigenetic regulation, discussion of cellular processes that rely on this kind of regulation, and surveys of model organisms in which epigenetic effects have been most studied. The original chapters have all been rewritten and brand new chapters cover topics such as the structure, function, and dynamics of histone-modifying enzymes and histone-interacting proteins. Other chapters address chromatin remodeling, DNA methylation, siRNAs, and gene silencing; X-chromosome inactivation, dosage compensation, and imprinting; and epigenetics in microbes, plants, insects, and mammals. How epigenetic mechanisms act in cell division and cell type specification, and how errors in these pathways contribute to cancer and other human diseases are also considered, along with the importance of epigenetics for induced pluripotency and reprogramming. In addition, new chapters describe the involvement of epigenetic processes in epigenetic inheritance, neuronal development, metabolism and signaling, responses to the environment, and long-range chromatin interactions. A series of short essays highlight important recent discoveries. All the chapters provide conceptual illustrations that help readers understand epigenetic control. The book is thus a benchmark text for advanced undergraduate and graduate courses on gene regulation, as well as an essential resource for scientists interested in this rapidly moving field.
650			_a Gene expression regulation _9858886
650			_a Genetic _9858887
650			_aZoology _9858888
700			_aAllis, C. David _9858885
700			_aCaparros, Marie Laure _9858889
700			_aJenuwein, Thomas _9858890
700			_aReinberg, Danny _9858891
942			_hK:6 P7;Q5 TK _cTB _2CC _n0
999			_c13809 _d13809